Effects of Ethanol Leaf and Fruit Extracts of Kigelia africana on Some Oxidative and Biochemical Parameters of Alloxan -Induced Diabetic Rats
E. N. Uhuo *
Department of Chemical Sciences, Godfrey Okoye University, Enugu, Nigeria
L. U. S. Ezeanyika
Department of Biochemistry, University of Nigeria, Nsukka, Nigeria
V. N. Ogugua
Department of Biochemistry, University of Nigeria, Nsukka, Nigeria
*Author to whom correspondence should be addressed.
Abstract
Hyperglycaemia, a characteristic feature of diabetics mellitus leads to decreased antioxidant defense and hence the development of oxidative stress, which is involved in the aetiology of development of diabetic complications. This work was therefore aimed at evaluating the anti diabetic and antioxidative potential of the plant. These evidences suggest that good glycemic control and/or use of antioxidants may play an important role in the prevention of complications associated with diabetes. Diabetes was induced with single Intra peritoneal injection of alloxan (160 mg/kg b.w) dissolved in freshly prepared citrate buffer (pH 4.5). Oral administration of Kingelia africana (500 mg/kg b.wt) of methanol leaves and fruits extracts resulted in significant (p>0.05) decrease in the blood glucose level, MDA, glycosylated haemoglobin, lipid profiles and liver maker enzymes with corresponding increase in SOD activity, catalase activity, glutathione activity, serum protein concentration, and Vit.C concentration. In conclusion, K. africana possessed antioxidative properties evidenced by decrease blood glucose level and its effect on some oxidative parameters of diabetic rats.
Keywords: Diabetes, alloxan, antioxidant, Kingelia africana