Asian Journal of Research in Biochemistry

Childhood obesity represents a multifactorial and progressive metabolic condition that poses significant short- and long-term threats to pediatric health. Beyond excessive fat accumulation, it disrupts endocrine, cardiovascular, hepatic, and immune systems, predisposing children to insulin resistance, type 2 diabetes mellitus, dyslipidemia, non-alcoholic fatty liver disease (NAFLD), and early-onset hypertension. This review explores the complex interplay of genetic, behavioral, and environmental factors underlying pediatric obesity, emphasizing the roles of adipokine imbalance, chronic inflammation, mitochondrial dysfunction, and gut microbiota dysbiosis in driving systemic metabolic derangements.

Critically, the convergence of these abnormalities in obese children often culminates in pediatric metabolic syndrome, setting the stage for lifelong cardiometabolic disease. Early-life influences—including maternal obesity, poor sleep hygiene, and urban food environments—further exacerbate risk. While lifestyle interventions remain the cornerstone of management, sustained progress depends on coordinated efforts across clinical, educational, and policy domains. School-based health programs, family-centered behavioral strategies, and regulatory frameworks limiting unhealthy food marketing are essential components of a comprehensive response.

In conclusion, childhood obesity demands urgent, multidimensional intervention. Recognizing early metabolic consequences and acting through personalized and public health approaches can prevent long-term complications, reduce societal burden, and improve the health trajectory of future generations.