Haematinic Effects of Aqueous Extract of Lophira lanceolata Leaves in Phenylhydrazine-induced Anaemia in Wistar Rats
Iserhienrhien Lucky Osafanme *
Department of Biology, Faculty of Science, Nigeria Maritime University, Okerenkoko, Delta State, Nigeria.
Sheneni Victor Duniya
Department of Biochemistry, Faculty of Natural Sciences, Kogi State University, Anyigba, Kogi State, Nigeria.
Nweje-Anyalowu Paul Chukwuemeka
Department of Biological Sciences, Biochemistry Unit, Faculty of Science, Clifford University, Owerrinta, Abia State, Nigeria.
Oguche Mercy
Department of Biochemistry, Faculty of Natural Sciences, Kogi State University, Anyigba, Kogi State, Nigeria.
Idakwoji Precious Adejoh
Department of Biochemistry, Faculty of Natural Sciences, Kogi State University, Anyigba, Kogi State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Aim: The haematinic activity of the aqueous extract of Lophira lanceolata leaves was investigated using rat model of phenylhydrazine-induced anaemia.
Methods and Results: Red Blood Cell (RBC) count, Haemoglobin (Hb) concentration and Packed Cell Volume (PCV) were analysed as indices of anaemia. Following phenylhydrazine administration to rats at a dose of 10 mg/kg for 8 days, a significant decrease (P<0.05) in the haematological parameters was observed indicating anaemia. However, treatment with graded doses (200, 400 and 800 mg/kg) of the aqueous extract of Lophira lanceolata leaves produced a significant (P<0.05) increase in the RBC count, Hb concentration and PCV time- and dose- dependently.
Conclusion: It was concluded that Lophira lanceolata leaves possess haematinic activity, making it useful in the management of anaemia.
Keywords: Haematinic, Lophira lanceolata, Phenylhydrazine, anaemia, wistar rats.