Lipid Profiles in Different ABO Blood Groups in Owerri Metropolis, South East Nigeria- A Preliminary Study
Samuel O. Ureme
Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, College of Medicine, University of Nigeria Enugu Campus, Nigeria
Innocent C. Anioke *
Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, College of Medicine, University of Nigeria Enugu Campus, Nigeria
C. Igboerika
Department of Medical Laboratory Sciences, Imo State University, Owerri, Nigeria
*Author to whom correspondence should be addressed.
Abstract
Objective: The study investigated the possibility of using blood groups as predictive indices for diseases associated with lipid metabolism.
Methods: Lipid profiles were examined in 100 apparently healthy male (40) and female (60) subjects of different ABO blood groups aged between 18-30 years from Imo State University. Of these, 20 were blood group A, 30 were B blood type, 4 were AB blood type, and 46 were blood group O. Lipid profile parameters were determined according to enzymatic assay using a commercial kit from Randox Laboratories, United Kingdom and calculation using Friedewald’s equation. Monoclonal ABO blood grouping reagent by CLAS Technology, United Kingdom was used to determine the blood group.
Results: Total Cholesterol (140.62 ± 21.66 mg/dl) and High-Density Lipoprotein (HDL) (96.20 ± 40.32 mg/dl) were highest in blood group B. Blood group A had the highest level of Triglyceride (80.84 ± 18.60 mg/dl) and Very Low-Density Lipoprotein (VLDL) (15.21 ± 6.24 mg/dl). Blood group O showed TC level of 130.60 ±34.76 mg/dl with the highest level of LDL (70.74 ± 20.15 mg/dl) and the lowest level of HDL (51.68 ± 20.50 mg/dl) compared to non- O blood types (P < 0.05).
Conclusion: The study revealed that blood group O might have a higher propensity for dyslipidemia, suggesting an increased risk for disease associated with lipid metabolism.
Keywords: ABO blood group, lipid metabolism, lipid profile, dyslipidemia