In-vivo Study on Organometallic Compounds as Anticancer Agents
F. Z. Mohammed *
Department of Biochemistry, Faculty of Science, Zagazig University, Egypt.
Elsherbiny H. Elsayed
Department of Organic Chemistry, Faculty of Science, Port Said University, Egypt.
Atef E. Abd Elbaky
Department of Biochemistry, Faculty of Pharmacy, Port Said University, Egypt.
H. M. Shalaby
Department of Biochemistry, Faculty of Science, Port Said University, Egypt.
*Author to whom correspondence should be addressed.
Abstract
This study aims to study the in-vivo anticancer effect of the synthesized copper complexes of 2,3-dihydroxy benzaldehyde thiosemicarbazone (3a,b), followed by evaluating their antioxidant activity. Materials and methods: A total number of 80 adult female swiss albino mice weighing 20-25 gm were divided into 8 groups (10 mice /each group). The acute toxicity was estimated by intraperitoneal injection of the compounds (3a, b). Results: We found that, 5 mg /kg and 10 mg /kg were considered to be the most effective dose of compounds 3a & 3b, respectively. The mean volume of EAC in the positive control group was found to be 4.2 ±0.5 (mL), this value was significantly decreased by 100%, (p<0.001) for 3a & 3b treated groups, respectively.
Keywords: Anticancer, copper complexes, 2,3-dihydroxy benzaldehyde thiosemicarbazone, Erhlich Ascites Carcinoma (EAC), swiss albino mice.